Drug Class | Mechanism of Action | Rehab Implications | Common Versions |
Beta Blocker* | Blocks Beta 1 receptors | Suppressed HR and BP response to activity | Metorolol (Lopressor), Propranolol (Inderal), Carvedilol (Coreg) |
Thiazide Diuretic* | Block Na+ reabsorption in the distal tubule of nephron | Orthostasis, volume depletion, frequent voiding, cramping | Hydrochlorothiazide “HCTZ”, (Esidrix) |
Loop Diuretic | Block the Na+/K+/2Cl- resorption in the loop of Henle | Orthostasis, volume depletion, frequent voiding, cramping | Furosomide (Lasix) |
Potassium Sparing Diuretic | Blocks Aldosterone | Orthostasis, volume depletion, frequent voiding | Sprirolactone (Aldactone) |
ACE-Inhibitor* | Inhibits formation of Angiotensin II | Orthostasis, Hypotension | Lisinopril (Zestril), Captopril (Capoten) and Enalapril (Vasotec) |
Angiotensin 2 Blocker (ARBs) | Blocks Angiotensin 2 receptors | Orthostasis, Hypotension | Losartan (Cozar), Valsartan (Diovan) |
Calcium Channel Blocker* | Block Ca2+ entry into vascular smooth muscle cells and cardiac myocytes | Orthostasis, dizziness, HA | Amlodipine(Norvasc), Diltiazem (Cardizem), Verapamil (Calan) |
Alpha 1 Blocker | Blocks Alpha 1 receptors in peripheral blood vessels | Orthostasis (may be seen more for BPH than HTN) | Doxazosin (Cardura), Prazosin (Minipress) |
Vasodilator | direct-acting smooth muscle relaxant | Tachycardia, HA, Palpitations (not used as often) | Hydralazine (Apresoline) |
*Indicates a medication class commonly observed in Physical Therapy practice.