Anticoagulants

Drug Class Common Versions Mechanism of Action  Indications Rehab Implications
Anti-coagulants Unfractionated Heparin Inactivating thrombin and activated factor X (factor Xa), effect time 24hrs Prevention and treatment of venous thrombosis and pulmonary embolism (PE), used in patients with impaired kidney function Increased risk of bleeding (check aPTT)
Anti-coagulants Low Molecular weight Heparin (Lovenox) Inactivating thrombin and activated factor X (factor Xa), effect time 3-5hrs Prevention and treatment of venous thrombosis and pulmonary embolism (PE) Increased risk of bleeding (check aPTT)
Anti-coagulants Warfarin (Coumadin) Blocks effect of Vitamin K-epoxide reductase Long term anticoagulation (Afib, Afib, Chronic DVT) Increased risk of bleeding (check INR)
Anti-coagulants Rivaroxaban (Xarelto) Direct factor Xa inhibitors Prevention and treatment of venous thrombosis and pulmonary embolism (PE), appears more ffective than LMWH with less dosage Increased bleading risk
Anti-platelets (ASA) Aspirin COX1 and COX2 inhibitor, prevents platelet aggregation Used in low doses to treat chronic clotting disorders, used in high dosages in acute events Increased bleading risk
Anti-platelets Clopridogrel (Plavix) ADP inhibitor, prevents platelet aggregation Used in low doses to treat chronic clotting disorders, used in high dosages in acute events Increased bleading risk
Thrombolytics (Tissue Plasminogen Activator Streptokinase (Streptase), UroKinase (Abbokinase) Facilitates breakdown of formed clots, by converting plasminogen to plasmin. Used to treat Acute MI, PE and CVA Patients may be held on bed rest 24-48hrs post TPA this is changing with new evidence